Children's, Intermediate and Advanced Online English Dictionary & Thesaurus

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drug abuse the use of illegal drugs, especially in a habitual or harmful way, or the use of any drug in doses or for purposes outside their intended medical use.
self-abuse blame or reproach of oneself. [2 definitions]
substance abuse habitual or harmful use of drugs, alcohol, or other substances that cause heightened mood or loss of inhibition, and which are usually addictive.