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downcast directed or cast downwards, as the eyes. [2 definitions]
downdraft an air current that flows downward.
Down East (sometimes l.c.) New England, esp. the state of Maine.
downer (informal) a drug that depresses or sedates, such as a barbiturate or tranquilizer. [2 definitions]
downfall a drastic decline in status, wealth, or the like; ruin. [3 definitions]
downgrade a slope downward, as in a road. [5 definitions]
downhearted sad or depressed; dejected.
downhill down a hill. [5 definitions]
down-home of, resembling, or characteristic of the qualities associated with rural folk or family, such as hospitality, simplicity, and warmth.
Downing Street the elected government of Great Britain, so termed because 10 Downing Street is the residence of the prime minister.
down in the mouth depressed; sad.
download to transfer (data, files, or programs) from a network or remote computer to one's own computer. [2 definitions]
down payment money to pay for part of the price of something that is very expensive.
downplay to dismiss the significance of; minimize.
downpour a very heavy rain.
downrange in the direction of the point taken as target, away from the launch site, on a missile test range.
downright absolute. [3 definitions]
downshift to shift a motor vehicle's transmission into a lower gear.
downside the lower or under side of something. [2 definitions]
downsize to design and manufacture a smaller version of (a popular product, esp. a car).
downspout a vertical drainpipe that carries rainwater or melted snow from a roof or gutter to the ground.