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adversity a condition of misfortune or difficulty. [1/2 definitions]
condole to express sympathy or sorrow for one suffering misfortune or pain.
curse an expression of a desire that someone or something might suffer lasting misfortune, or, in tales of magic, a spell that brings lasting misfortune. [5/9 definitions]
dire warning of misfortune or calamity. [1/3 definitions]
direful boding misfortune. [1/2 definitions]
fatal leading to misfortune, ruin, or destruction. [1/4 definitions]
forebode to have a presentiment or premonition of (impending misfortune). [1/4 definitions]
happen to have the accidental lot, luck, or misfortune (to be in a specified situation or do something specified); chance. [1/4 definitions]
ill-fated bringing misfortune; unlucky. [1/2 definitions]
infelicity an instance of misfortune. [1/3 definitions]
knell a sound or other signal of misfortune, conclusion, or failure. [1/6 definitions]
misadventure an instance of misfortune or bad luck; accident or mishap.
misery a state of need and suffering caused by poverty, illness, or other misfortune. [1/3 definitions]
night a state or period of depression, ignorance, grief, or misfortune. [1/5 definitions]
patience the ability to steadfastly endure misfortune, pain, or hardship. [1/3 definitions]
patient enduring misfortune, pain, or hardship calmly or without complaining. [1/7 definitions]
play it safe to act so as to prevent or avoid misfortune or danger; be cautious.
schadenfreude (often cap.) pleasure derived from the misfortune of others.
sorrow the suffering or distress resulting from an injury, loss, misfortune, or the like; grief; sadness. [1/4 definitions]
sorry resulting in misfortune, grief, or regret. [1/5 definitions]
suffer to experience pain, misfortune, or distress. [1/6 definitions]