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bittersweet both pleasurable and painful. [1/5 definitions]
boil2 a swollen, painful sore that is filled with pus and is caused by a bacterial infection.
bursitis a painful disorder caused by the inflammation of a bursa, esp. in a joint of the shoulder, elbow, or knee.
Calvary (sometimes l.c.) a place or occasion of severe trial, or an intensely painful, anguishing experience. [1/2 definitions]
carbuncle a painful localized abscess of the tissue underneath the skin. [1/2 definitions]
charley horse a painful cramp in a muscle caused by overexertion or by a blow.
cramp1 (sometimes pl.) a painful and debilitating contraction or spasm of any muscle of the body. [1/3 definitions]
crick a painful stiffness or cramp, esp. in the neck or back. [1/2 definitions]
decompression sickness a painful and sometimes fatal condition caused by the formation of nitrogen bubbles in the blood, resulting from returning to atmospheric pressure too quickly from deep water or a compression chamber; aeroembolism; bends.
defense mechanism in psychology, an unconscious process that submerges or opposes ideas or actions that would be painful or inappropriate. [1/2 definitions]
diverticulitis painful inflammation of a sac that branches off from a hollow organ, esp. the intestine.
dysmenorrhea menstruation that is difficult or painful.
dyspareunia sexual intercourse that is difficult or painful.
earsplitting loud and shrill enough to be painful to the ears.
ease to become less painful, difficult, or anxious. [1/10 definitions]
embarrassed experiencing, expressing, or marked by feelings of shame, painful self-consciousness, or unease. [1/2 definitions]
embarrassing causing or accompanied by feelings of shame, painful self-consciousness, or unease.
euthanasia the act of putting to a painless death a person or animal suffering from a painful, incurable disease or injury; mercy killing.
excruciating extremely painful or intensely distressing; agonizing. [1/2 definitions]
gout a painful disorder characterized by the accumulation of uric acid salts in the joints. [1/2 definitions]
grievous causing emotional or physical suffering; painful. [1/3 definitions]