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Comprehensive
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in hot water (informal) in a bad situation; in trouble.
jam1 (informal) a difficulty or embarrassment not easily resolved; trouble or predicament. [1/12 definitions]
lead a dog's life to have a life of misery and trouble.
matter problem or trouble (prec. by "the"; often fol. by "with"). [1/8 definitions]
mischief-maker a person who creates trouble or discord among others, esp. by gossiping.
Moab Isolation Center a special U.S. internment camp located near Moab, Utah, occupied in 1943 by American citizens of Japanese descent who had been deemed to be "trouble-makers" during their previous internment at ordinary camps created for the holding of Japanese-Americans during World War II. The conditions at the Moab Isolation Center were harsher than at other camps. At its peak, there were about fifty people being held there.
moil confusion, agitation, or trouble; turmoil. [1/4 definitions]
nag1 to trouble or make uncomfortable, persistently or recurrently. [1/6 definitions]
peck1 (informal) a large amount, esp. of trouble; lot. [1/4 definitions]
play ball (slang) to do exactly as requested, esp. to avoid trouble or harm to oneself or others.
pother to trouble, confuse, or bother; worry. [2/4 definitions]
put to to cause (someone) trouble or inconvenience. [1/3 definitions]
raise hob with to cause a commotion; disrupt; trouble.
red flag (informal) anything that signals trouble or danger ahead. [1/2 definitions]
rend to trouble or distress (the heart, spirit, or the like). [1/4 definitions]
rhyming slang a form of language play in which one word or phrase is replaced with another that rhymes with the intended one, such as "trouble and strife" for "wife".
salvation something that has the effect of saving or protecting from trouble or harm. [1/3 definitions]
serene free from trouble or disturbance; unruffled; tranquil. [1/3 definitions]
snitch (informal) to tell someone in authority what another person has done, which will likely bring trouble to that other person (often fol. by "on"). [1/3 definitions]
stormy petrel a person who tends to cause trouble; rebel. [1/2 definitions]
threat a warning or sense of impending trouble or harm. [1/3 definitions]