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downstage at or toward the front portion of a stage. [3 definitions]
downstairs at, to, or on a lower floor. [3 definitions]
downstate the southern part of any U.S. state. (Cf. upstate.) [2 definitions]
downstream in the direction that a stream or current is flowing. [3 definitions]
downswing a swing in a downward direction, as of a golf club. [2 definitions]
down the drain to no good purpose; wasted.
downtime a period of time during which a computer, factory, or the like is inactive, usu. to allow for repairs or the like.
down-to-earth practical, straightforward, sensible, and realistic.
downtown at, to, or toward the lower part or the business area of a town or city. [3 definitions]
downtrodden oppressed by those in positions of power; tyrannized over; crushed.
downturn a turn or tendency downward, as in business or the economy; decline.
down under (informal) Australia or New Zealand.
downward toward a lower place, state, condition, or the like. [3 definitions]
downwind in the direction that the wind is going; leeward.
downy resembling, or of the softness of, down. [2 definitions]
dowry the money or other property brought by a woman to her husband at marriage. [2 definitions]
dowse to search with a divining rod for underground water or minerals.
dowser a person who uses a divining rod to search for underground water; water witch.
doxology a formal expression of praise to God.
doxycycline a tetracycline antibiotic used to treat infections of bacteria and protozoa.
doyen the senior or highest-ranking male member of a group.