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adulterate sexually unfaithful to one's spouse, or tainted by unfaithfulness; adulterous. [1/3 definitions]
betray to be unfaithful to. [1/5 definitions]
cheat (informal) to be sexually unfaithful or untrue (often fol. by "on"). [1/11 definitions]
disloyal unfaithful to one's duty or allegiance.
Othello in a tragedy by William Shakespeare, the title character, who murders his wife in the mistaken belief that she has been unfaithful.