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Comprehensive
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impossibly to a degree that causes difficulty or makes a solution unattainable. [1/3 definitions]
inconvenience a thing or situation that causes difficulty. [1/3 definitions]
indigestion inability to digest, or difficulty in digesting food. [2 definitions]
insomnia difficulty in getting to sleep, esp. as a persistent problem.
insomniac a person who has chronic difficulty in getting to sleep. [1/3 definitions]
jam1 (informal) a difficulty or embarrassment not easily resolved; trouble or predicament. [1/12 definitions]
kicker a hidden difficulty; pitfall. [1/3 definitions]
labor to proceed with difficulty. [1/9 definitions]
labored produced with difficulty or effort. [1/2 definitions]
laryngitis an inflammation of the larynx, usu. marked by difficulty in making the voice audible.
learning disability any of various conditions, thought to be associated with the nervous system, that cause difficulty in mastering a basic skill such as reading.
lie2 the position of a golf ball in relation to the difficulty of the next shot. [1/8 definitions]
manage to accomplish or succeed in, usu. despite some difficulty. [1/6 definitions]
mountain sickness nausea, weakness, and difficulty in breathing at high altitudes, caused by lack of oxygen.
open-and-shut (informal) not requiring much deliberation; not presenting ambiguity or difficulty; immediately obvious.
pain (informal) a person or thing that causes irritation or difficulty. [1/7 definitions]
peer2 to look closely, searchingly, or with difficulty. [1/2 definitions]
perplexing causing difficulty in understanding or in figuring out a solution or a way to proceed.
plow to proceed with determination and with difficulty into or through something. [1/11 definitions]
pluck strong resolve, courage, or spirit in spite of difficulty. [1/8 definitions]
plucky spirited and courageous in the face of difficulty.