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despise to hate or feel contempt for.
despite notwithstanding; regardless of. [3 definitions]
despoil to forcefully take belongings or goods from; plunder.
despoliation the action of forcefully seizing goods or belongings. [2 definitions]
despond to become discouraged and have low spirits, as from loss of hope or courage.
despondency the condition of one who is dejected by hopelessness or loss of courage.
despondent low in spirits; unhappy, depressed, or dejected.
despot a ruler who has complete power and authority. [2 definitions]
despotic of or resembling a tyrant; autocratic or dictatorial.
despotism the rule or practices of a tyrant; autocracy or tyranny. [3 definitions]
despumate to remove scum from; skim. [3 definitions]
desquamate to peel or scale, as the skin in certain pathological conditions.
dessert a sweet or fruit served as the last course of a meal.
dessertspoon a spoon that is between a tablespoon and a teaspoon in size and is used for eating dessert. [2 definitions]
destabilize to upset the equilibrium of (esp. a government or other organization); unbalance, often with intent to topple.
destination the planned end of a journey, or the place to which goods or baggage are sent. [2 definitions]
destine to specify for or send toward a particular place, end, or purpose. [2 definitions]
destiny that which has happened or must happen to someone or something because of fate or luck. [3 definitions]
destitute having no money or other means of living; impoverished. [2 definitions]
destitution utter poverty, or the extreme want of the necessities of life. [2 definitions]
destroy to damage beyond repair; ruin. [5 definitions]