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catastrophe a calamity with widespread effects; disaster. [1/3 definitions]
dire warning of misfortune or calamity. [1/3 definitions]
disaster a sudden calamity, esp. one causing widespread damage or suffering such as an earthquake, flood, oil spill, or fire. [1/2 definitions]
done for having lost one's means of support, or having suffered some other calamity; ruined. [1/2 definitions]
tragedy a disastrous occurrence; calamity. [1/2 definitions]