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Comprehensive
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clonidine a drug used esp. to treat hypertension and migraine headaches, and to diminish opioid and nicotine withdrawal symptoms.
fentanyl a potent, fast-acting synthetic opioid that is used pharmacologically for pain relief and is also used illicitly.
opioid any natural or synthetic compound, including heroin, morphine, and certain prescription pain relievers, that binds opioid receptors and has an analgesic or narcotic effect. [1/2 definitions]
opioid epidemic a rapid increase in the use of prescription and non-prescription opioid drugs, beginning in the late 1990s and continuing into the early decades of the 2000s.