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Comprehensive
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abrasion a spot or patch that has been scraped, as on the skin. [1/2 definitions]
ace a playing card or die face that bears only one spot. [1/7 definitions]
Achilles the hero of The Iliad, who is killed by an arrow in his heel, his only vulnerable spot.
Achilles heel any vulnerable or weak spot, part, or trait.
aphtha a small white spot or blister on the lips or in the mouth or intestines that is a symptom of certain viral or fungal infections.
blaze2 a spot or mark on a tree to show a trail. [1/3 definitions]
blind spot an area nearby but which, or in which, one cannot see or hear what is happening, such as an area behind an automobile in motion that the driver cannot see through a rear-view mirror, or an acoustically dead spot in an auditorium. [1/4 definitions]
blip a bright spot on a radar screen, used as an indicator. [1/5 definitions]
blot a spot or stain. [3/4 definitions]
darn1 a mended spot, as in a sock. [1/2 definitions]
depression a low spot or hollow. [1/4 definitions]
dot a small, round mark or spot. [1/3 definitions]
eyespot a spot that looks like an eye, as on the tail of a peacock. [1/2 definitions]
flyspeck a small spot or speck made by a fly's excrement. [2/3 definitions]
freckle any spot resembling a freckle. [1/3 definitions]
fret1 a worn spot, hole, or passage formed by erosion or corrosion. [1/8 definitions]
hollow a low or sunken spot or area, esp. a small valley. [1/10 definitions]
inkblot a spot or stain of or like ink on paper. [1/2 definitions]
itch (informal) to scratch (a spot that itches). [1/8 definitions]
knot1 the place where a branch grows out of the trunk of a tree. When wood is cut into boards, the knot looks like a dark spot. [1/6 definitions]
liver spot a red, black, or yellowish brown spot or area on the skin, formerly thought to be caused by malfunctioning of the liver.